http://content.nejm.org/Browse NEJM’s most-viewed clinical and medical articles to see what your colleagues are viewing most often. These clinical and medical articles are listed in rank order, and the list is updated daily.http://content.nejm.org/icons/nejm_name_220.gifhttp://content.nejm.org/Tue, 13 May 2008 06:30:33 GMTThe New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.en-usThe current era of research in antiangiogenic therapy for cancer began in earnest in 1971 with the publication of Folkman's imaginative hypothesis,1 but 33 years would elapse before the first...http://content.nejm.org/cgi/content/short/358/19/2039?ssource=mfvReview ArticleRobert S. Kerbel, Ph.D.Thu, 08 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/19/2039?ssource=mfvBackground: Early repolarization is a common electrocardiographic finding that is generally considered to be benign. Its potential to cause cardiac arrhythmias has been hypothesized from experimental studies, but it is...http://content.nejm.org/cgi/content/short/358/19/2016?ssource=mfvOriginal ArticleMichel Haïssaguerre, M.D., Nicolas Derval, M.D., Frederic Sacher, M.D., Laurence Jesel, M.D., Isabel Deisenhofer, M.D., Luc de Roy, M.D., Jean-Luc Pasquié, M.D., Ph.D., Akihiko Nogami, M.D., Dominique Babuty, M.D., Sinikka Yli-Mayry, M.D., Christian De Chillou, M.D., Patrice Scanu, M.D., Philippe Mabo, M.D., Seiichiro Matsuo, M.D., Vincent Probst, M.D., Ph.D., Solena Le Scouarnec, Ph.D., Pascal Defaye, M.D., Juerg Schlaepfer, M.D., Thomas Rostock, M.D., Dominique Lacroix, M.D., Dominique Lamaison, M.D., Thomas Lavergne, M.D., Yoshifusa Aizawa, M.D., Anders Englund, M.D., Frederic Anselme, M.D., Mark O'Neill, M.D., Meleze Hocini, M.D., Kang Teng Lim, M.B., B.S., Sebastien Knecht, M.D., George D. Veenhuyzen, M.D., Pierre Bordachar, M.D., Michel Chauvin, M.D., Pierre Jais, M.D., Gaelle Coureau, Ph.D., Genevieve Chene, Ph.D., George J. Klein, M.D., and Jacques Clémenty, M.D.Thu, 08 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/19/2016?ssource=mfvBackground: Metformin is a logical treatment for women with gestational diabetes mellitus, but randomized trials to assess the efficacy and safety of its use for this condition are lacking. ...http://content.nejm.org/cgi/content/short/358/19/2003?ssource=mfvOriginal ArticleJanet A. Rowan, M.B., Ch.B., William M. Hague, M.D., Wanzhen Gao, Ph.D., Malcolm R. Battin, M.B., Ch.B., and M. Peter Moore, M.B., Ch.B., for the MiG Trial InvestigatorsThu, 08 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/19/2003?ssource=mfvA 44-year-old woman desires weight reduction. Her history is notable for hypertension, snoring, daytime somnolence, and osteoarthritis. Her father was obese and had type 2 diabetes. On physical examination, her...http://content.nejm.org/cgi/content/short/358/18/1941?ssource=mfvClinical PracticeRobert H. Eckel, M.D.Thu, 01 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/18/1941?ssource=mfvBackground: It is controversial whether maternal hyperglycemia less severe than that in diabetes mellitus is associated with increased risks of adverse pregnancy outcomes. A total of 25,505 pregnant women...http://content.nejm.org/cgi/content/short/358/19/1991?ssource=mfvOriginal ArticleThe HAPO Study Cooperative Research GroupThu, 08 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/19/1991?ssource=mfvPatients ideally deserve to have a compassionate doctor, but might they be satisfied with one who is simply well-behaved? When I hear patients complain about doctors, their criticism often has...http://content.nejm.org/cgi/content/short/358/19/1988?ssource=mfvPerspectiveMichael W. Kahn, M.D.Thu, 08 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/19/1988?ssource=mfvBackground: Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the...http://content.nejm.org/cgi/content/short/358/18/1887?ssource=mfvOriginal ArticleNigel S. Beckett, M.B., Ch.B., Ruth Peters, Ph.D., Astrid E. Fletcher, Ph.D., Jan A. Staessen, M.D., Ph.D., Lisheng Liu, M.D., Dan Dumitrascu, M.D., Vassil Stoyanovsky, M.D., Riitta L. Antikainen, M.D., Ph.D., Yuri Nikitin, M.D., Craig Anderson, M.D., Ph.D., Alli Belhani, M.D., Françoise Forette, M.D., Chakravarthi Rajkumar, M.D., Ph.D., Lutgarde Thijs, M.Sc., Winston Banya, M.Sc., and Christopher J. Bulpitt, M.D., for the HYVET Study GroupThu, 01 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/18/1887?ssource=mfvDr. David T. Plante (Psychiatry): A 78-year-old man was admitted to the inpatient psychiatry service of this hospital because of anergia and anhedonia. Thirty-three months before admission, the patient was...http://content.nejm.org/cgi/content/short/358/19/2051?ssource=mfvCase Records of the Massachusetts General HospitalJeffery C. Huffman, M.D., Lawrence T. Park, M.D., Charles A. Welch, M.D., Andrew A. Nierenberg, M.D., James L. Januzzi, Jr., M.D., and Stuart R. Pomerantz, M.D.Thu, 08 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/19/2051?ssource=mfvAn 83-year-old woman with long-standing atrial fibrillation who had previously undergone atrioventricular nodal ablation and pacemaker placement presented with symptoms of progressive heart failure. Physical examination was notable for elevated...http://content.nejm.org/cgi/content/short/358/19/2050?ssource=mfvImages in Clinical MedicineGarrick C. Stewart, M.D., Anju Nohria, M.D.Thu, 08 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/19/2050?ssource=mfvPhotodynamic therapy is a noninvasive therapy for nonhyperkeratotic actinic keratoses and basal-cell carcinoma. Photodynamic therapy involves the activation of a photosensitizing drug by visible light to produce activated oxygen species...http://content.nejm.org/cgi/content/short/358/19/e21?ssource=mfvImages in Clinical MedicineOnofre Sanmartin, M.D., Carlos Guillen, M.D.Thu, 08 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/19/e21?ssource=mfv