http://content.nejm.org/Browse the NEJM articles that have been most widely covered in the press. Stay abreast of which NEJM articles the general public is hearing about most often in the media. These NEJM articles cover a range of topics. Articles are listed in rank order, and the list is updated weekly.http://content.nejm.org/icons/nejm_name_220.gifhttp://content.nejm.org/The New England Journal of Medicine is owned, published, and copyrighted © 2007 Massachusetts Medical Society. All rights reserved.en-usMon, 05 May 2008 00:00:00 GMTEarly-onset, severe retinal dystrophy caused by mutations in the gene encoding retinal pigment epithelium–specific 65-kDa protein ( RPE65 ) is associated with poor vision at birth and complete loss of...http://content.nejm.org/cgi/content/full/NEJMoa0802268?rss=1&ssource=mostCitedInMediaOriginal ArticleJames W.B. Bainbridge, Ph.D., F.R.C.Ophth., Alexander J. Smith, Ph.D., Susie S. Barker, Ph.D., Scott Robbie, M.R.C.Ophth., Robert Henderson, M.R.C.Ophth., Kamaljit Balaggan, M.R.C.Ophth., Ananth Viswanathan, M.D., F.R.C.Ophth., Graham E. Holder, Ph.D., Andrew Stockman, Ph.D., Nick Tyler, Ph.D., Simon Petersen-Jones, Ph.D., Shomi S. Bhattacharya, Ph.D., Adrian J. Thrasher, Ph.D., M.R.C.P., F.R.C.P., Fred W. Fitzke, Ph.D., Barrie J. Carter, Ph.D., Gary S. Rubin, Ph.D., Anthony T. Moore, F.R.C.Ophth., and Robin R. Ali, Ph.D.Tue, 13 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/full/NEJMoa0802268?rss=1&ssource=mostCitedInMedia?rss=1&ssource=mostCitedInMediaLeber's congenital amaurosis (LCA) is a group of inherited blinding diseases with onset during childhood. One form of the disease, LCA2, is caused by mutations in the retinal pigment epithelium–specific...http://content.nejm.org/cgi/content/full/NEJMoa0802315?rss=1&ssource=mostCitedInMediaOriginal ArticleAlbert M. Maguire, M.D., Francesca Simonelli, M.D., Eric A. Pierce, M.D., Ph.D., Edward N. Pugh, Jr., Ph.D., Federico Mingozzi, Ph.D., Jeannette Bennicelli, Ph.D., Sandro Banfi, M.D., Kathleen A. Marshall, C.O.T., Francesco Testa, M.D., Enrico M. Surace, D.V.M., Settimio Rossi, M.D., Arkady Lyubarsky, Ph.D., Valder R. Arruda, M.D., Barbara Konkle, M.D., Edwin Stone, M.D., Ph.D., Junwei Sun, M.S., Jonathan Jacobs, Ph.D., Lou Dell'Osso, Ph.D., Richard Hertle, M.D., Jian-xing Ma, M.D., Ph.D., T. Michael Redmond, Ph.D., Xiaosong Zhu, M.D., Bernd Hauck, Ph.D., Olga Zelenaia, Ph.D., Kenneth S. Shindler, M.D., Ph.D., Maureen G. Maguire, Ph.D., J. Fraser Wright, Ph.D., Nicholas J. Volpe, M.D., Jennifer Wellman McDonnell, M.S., Alberto Auricchio, M.D., Katherine A. High, M.D., and Jean Bennett, M.D., Ph.D.Tue, 13 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/full/NEJMoa0802315?rss=1&ssource=mostCitedInMedia?rss=1&ssource=mostCitedInMediaIn this issue of the Journal, two groups of investigators — Bainbridge et al.1 and Maguire et al.2 — describe the first results of separate clinical trials investigating the short-term...http://content.nejm.org/cgi/content/full/NEJMe0803081?rss=1&ssource=mostCitedInMediaEditorialJoan W. Miller, M.D.Tue, 13 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/full/NEJMe0803081?rss=1&ssource=mostCitedInMedia?rss=1&ssource=mostCitedInMediaBackground: We previously reported that, in a randomized trial, carotid stenting with the use of an emboli-protection device is not inferior to carotid endarterectomy for the treatment of carotid artery...http://content.nejm.org/cgi/content/short/358/15/1572?rss=1&ssource=mostCitedInMediaOriginal ArticleHitinder S. Gurm, M.D., Jay S. Yadav, M.D., Pierre Fayad, M.D., Barry T. Katzen, M.D., Gregory J. Mishkel, M.D., Tanvir K. Bajwa, M.D., Gary Ansel, M.D., Neil E. Strickman, M.D., Hong Wang, M.D., M.P.H., Sidney A. Cohen, M.D., Ph.D., Joseph M. Massaro, Ph.D., and Donald E. Cutlip, M.D., for the SAPPHIRE InvestigatorsThu, 10 Apr 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/15/1572?rss=1&ssource=mostCitedInMedia?rss=1&ssource=mostCitedInMediaBackground: Bone mineral density influences the risk of osteoporosis later in life and is useful in the evaluation of the risk of fracture. We aimed to identify sequence variants associated...http://content.nejm.org/cgi/content/full/NEJMoa0801197?rss=1&ssource=mostCitedInMediaOriginal ArticleUnnur Styrkarsdottir, Ph.D., Bjarni V. Halldorsson, Ph.D., Solveig Gretarsdottir, Ph.D., Daniel F. Gudbjartsson, Ph.D., G. Bragi Walters, B.Sc., Thorvaldur Ingvarsson, M.D., Ph.D., Thorbjorg Jonsdottir, B.Sc., Jona Saemundsdottir, B.Sc., Jacqueline R. Center, M.B., B.S., Ph.D., Tuan V. Nguyen, Ph.D., Yu Bagger, M.D., Jeffrey R. Gulcher, M.D., Ph.D., John A. Eisman, M.B., B.S., Ph.D., Claus Christiansen, M.D., Gunnar Sigurdsson, M.D., Ph.D., Augustine Kong, Ph.D., Unnur Thorsteinsdottir, Ph.D., and Kari Stefansson, M.D., Ph.D.Tue, 13 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/full/NEJMoa0801197?rss=1&ssource=mostCitedInMedia?rss=1&ssource=mostCitedInMediaBackground: A single infusion of intravenous zoledronic acid decreases bone turnover and improves bone density at 12 months in postmenopausal women with osteoporosis. We assessed the effects of annual infusions...http://content.nejm.org/cgi/content/short/356/18/1809?rss=1&ssource=mostCitedInMediaOriginal ArticleDennis M. Black, Ph.D., Pierre D. Delmas, M.D., Ph.D., Richard Eastell, M.D., Ian R. Reid, M.D., Steven Boonen, M.D., Ph.D., Jane A. Cauley, Dr.P.H., Felicia Cosman, M.D., Péter Lakatos, M.D., Ph.D., Ping Chung Leung, M.D., Zulema Man, M.D., Carlos Mautalen, M.D., Peter Mesenbrink, Ph.D., Huilin Hu, Ph.D., John Caminis, M.D., Karen Tong, B.S., Theresa Rosario-Jansen, Ph.D., Joel Krasnow, M.D., Trisha F. Hue, M.P.H., Deborah Sellmeyer, M.D., Erik Fink Eriksen, M.D., D.M.Sc., and Steven R. Cummings, M.D., for the HORIZON Pivotal Fracture TrialThu, 03 May 2007 00:00:00 GMThttp://content.nejm.org/cgi/content/short/356/18/1809?rss=1&ssource=mostCitedInMedia?rss=1&ssource=mostCitedInMediaBackground: Evidence-based medicine is valuable to the extent that the evidence base is complete and unbiased. Selective publication of clinical trials — and the outcomes within those trials — can...http://content.nejm.org/cgi/content/short/358/3/252?rss=1&ssource=mostCitedInMediaSpecial ArticleErick H. Turner, M.D., Annette M. Matthews, M.D., Eftihia Linardatos, B.S., Robert A. Tell, L.C.S.W., and Robert Rosenthal, Ph.D.Thu, 17 Jan 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/3/252?rss=1&ssource=mostCitedInMedia?rss=1&ssource=mostCitedInMediaBackground: Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density lipoprotein (LDL) cholesterol when added to statin treatment. However, the effect of ezetimibe on the progression of atherosclerosis remains unknown. ...http://content.nejm.org/cgi/content/short/358/14/1431?rss=1&ssource=mostCitedInMediaOriginal ArticleJohn J.P. Kastelein, M.D., Ph.D., Fatima Akdim, M.D., Erik S.G. Stroes, M.D., Ph.D., Aeilko H. Zwinderman, Ph.D., Michiel L. Bots, M.D., Ph.D., Anton F.H. Stalenhoef, M.D., Ph.D., F.R.C.P., Frank L.J. Visseren, M.D., Ph.D., Eric J.G. Sijbrands, M.D., Ph.D., Mieke D. Trip, M.D., Ph.D., Evan A. Stein, M.D., Ph.D., Daniel Gaudet, M.D., Ph.D., Raphael Duivenvoorden, M.D., Enrico P. Veltri, M.D., A. David Marais, M.D., Ph.D., and Eric de Groot, M.D., Ph.D., for the ENHANCE InvestigatorsThu, 03 Apr 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/short/358/14/1431?rss=1&ssource=mostCitedInMedia?rss=1&ssource=mostCitedInMediaBackground: Rosiglitazone is widely used to treat patients with type 2 diabetes mellitus, but its effect on cardiovascular morbidity and mortality has not been determined. We conducted searches of...http://content.nejm.org/cgi/content/short/356/24/2457?rss=1&ssource=mostCitedInMediaOriginal ArticleSteven E. Nissen, M.D., and Kathy Wolski, M.P.H.Thu, 14 Jun 2007 00:00:00 GMThttp://content.nejm.org/cgi/content/short/356/24/2457?rss=1&ssource=mostCitedInMedia?rss=1&ssource=mostCitedInMediaBackground: There is an urgent need to determine whether oversulfated chondroitin sulfate (OSCS), a compound contaminating heparin supplies worldwide, is the cause of the severe anaphylactoid reactions that have occurred...http://content.nejm.org/cgi/content/full/NEJMoa0803200?rss=1&ssource=mostCitedInMediaOriginal ArticleTakashi Kei Kishimoto, Ph.D., Karthik Viswanathan, Ph.D., Tanmoy Ganguly, Ph.D., Subbiah Elankumaran, Ph.D., Sean Smith, B.S., Kevin Pelzer, Ph.D., Jonathan C. Lansing, Ph.D., Nammalwar Sriranganathan, Ph.D., Ganlin Zhao, M.D., Zoya Galcheva-Gargova, Ph.D., Ali Al-Hakim, Ph.D., Gregory Scott Bailey, B.S., Blair Fraser, Ph.D., Sucharita Roy, Ph.D., Thomas Rogers-Cotrone, M.S., Lucinda Buhse, Ph.D., Mark Whary, Ph.D., James Fox, Ph.D., Moheb Nasr, Ph.D., Gerald J. Dal Pan, M.D., Zachary Shriver, Ph.D., Robert S. Langer, Sc.D., Ganesh Venkataraman, Ph.D., K. Frank Austen, M.D., Janet Woodcock, M.D., and Ram Sasisekharan, Ph.D.Tue, 13 May 2008 00:00:00 GMThttp://content.nejm.org/cgi/content/full/NEJMoa0803200?rss=1&ssource=mostCitedInMedia?rss=1&ssource=mostCitedInMedia